New Step by Step Map For ceesdekker

New Step by Step Map For ceesdekker

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Nanotechnology offers A selection of chances to contribute to biology. Below I'll present examples the place nanofabrication – a chance to make confined buildings with Proportions at will – is used to examine the biophysics of single molecules and cells. I will present some examples from our lab:

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A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola

2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and initial ever study with the dynamics DNA supercoils and the discovery of supercoil hopping

The coiled-coil from the human Rad50 DNA maintenance protein is made up of particular segments of amplified overall flexibility

Duration Charge of specific carbon nanotubes by nanostructuring Together with the scanning tunneling microscope

2011, initial in vitro measurements of transport across a single biomimetic nuclear pore complicated; improvement of multiplexed magnetic tweezers for kilo-molecule experiments; and resolved the system of homology recognition in DNA homologous recombination

Knowing basic processes regulating the spatial and dynamic organisation in the DNA in Reside cells.

‘The fantastically refined way through which factors in nature functionality hardly ever ceases to amaze me. If we clear up the puzzle of how lifetime came into becoming, I expect that my amazement within the complexity of generation could have improved and with it my awe for the greatness of your Creator.’

FtsZ treadmilling is essential for Z-ring condensation and septal constriction initiation in bacterial cell division

‘That fears the synthetic mobile, as part of the Dutch BaSyC initiative. Craig Venter seemed major-down ceesdekker.net in Individuals times and identified about five hundred genes which have been minimally necessary for your functioning cell. We wish to glimpse bottom-up: how can we shift from a handful of molecules to an entire biological technique?

For instance, we look at the nucleopore elaborate, a gateway involving the cell nucleus and also the cytoplasm. This is a really challenging program and therefore difficult to analyze in a very cell, so we use biomimetics. We reconstruct holes and then insert particular person aspects from the nucleopore elaborate to review transport by way of it at the single-molecule amount.’

2013, managed shaping of Reside bacterial cells into arbitrary styles; and discovery of spontaneous fluctuations within the handedness of histone tetrasomes